Publications
2008
- Pichota, Arkadius; Duraiswamy, Jeyaraj; Yin, Zheng; Keller, Thomas H.; Alam, Jenefer; Liung, Sarah; Lee, Gladys; Ding, Mei; Wang, Gang; Chan, Wai Ling; Schreiber, Mark; Ma, Ida; Beer, David; Ngew, Xinyi; Mukherjee, Kakoli; Nanjundappa, Mahesh; Teo, Jeanette W. P.; Thayalan, Pamela; Yap, Amelia; Dick, Thomas; Meng, Wuyi; Xu, Mei; Koehn, James; Pan, Shi-Hao; Clark, Kirk; Xie, Xiaoling; Shoen, Carolyn; Cynamon, Michael. Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results. Bioorganic & Medicinal Chemistry Letters (2008), 18(24), 6568-6572.
- Prathipati, Philip; Ma, Ngai Ling; Keller, Thomas H.. Global Bayesian Models for the Prioritization of Antitubercular Agents. Journal of Chemical Information and Modeling (2008), 48(12), 2362-2370.
- Umareddy, Indira; Tang, Kin Fai; Vasudevan, Subhash G.; Devi, Shamala; Hibberd, Martin L.; Gu, Feng. Dengue virus regulates type I interferon signalling in a strain-dependent manner in human cell lines. Journal of General Virology (2008), 89(12), 3052-3062.
- Lim, Siew Pheng; Wen, Daying; Yap, Thai Leong; Yan, Chung Ka; Lescar, Julien; Vasudevan, Subhash G.. A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses. Antiviral Research (2008), 80(3), 360-369.
- Luo, Dahai; Xu, Ting; Watson, Randall P.; Scherer-Becker, Daniella; Sampath, Aruna; Jahnke, Wolfgang; Yeong, Sui Sum; Wang, Chern Hoe; Lim, Siew Pheng; Strongin, Alex; Vasudevan, Subhash G.; Lescar, Julien. Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein. EMBO Journal (2008), 27(23), 3209-3219.
- Lescar, Julien; Luo, Dahai; Xu, Ting; Sampath, Aruna; Lim, Siew Pheng; Canard, Bruno; Vasudevan, Subhash G.. Towards the design of antiviral inhibitors against flaviviruses: The case for the multifunctional NS3 protein from Dengue virus as a target. Antiviral Research (2008), 80(2), 94-101.
- Singh R, Manjunatha U, Boshoff HI, Ha YH, Niyomrattanakit P, Ledwidge R, Dowd CS, Lee IY, Kim P, Zhang L, Kang S, Keller TH, Jiricek J, Barry CE 3rd. PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science (2008), 322(5906):1392-5.
- Gengenbacher, Martin; Xu, Ting; Niyomrattanakit, Pornwaratt; Spraggon, Glen; Dick, Thomas. Biochemical and structural characterization of the putative dihydropteroate synthase ortholog Rv1207 of Mycobacterium tuberculosis. FEMS Microbiology Letters (2008), 287(1), 128-135.
- Rao, Srinivasa P. S.; Alonso, Sylvie; Rand, Lucinda; Dick, Thomas; Pethe, Kevin. The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America (2008), 105(33), 11945-11950.
- Kurabachew, Mekonnen; Lu, Stephen H. J.; Krastel, Philipp; Schmitt, Esther K.; Suresh, Bangalore L.; Goh, Anne; Knox, John E.; Ma, Ngai Ling; Jiricek, Jan; Beer, David; Cynamon, Michael; Petersen, Frank; Dartois, Veronique; Keller, Thomas; Dick, Thomas; Sambandamurthy, Vasan K. Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis. Journal of Antimicrobial Chemotherapy (2008), 62(4), 713-719.
- Kroschewski, Helga; Lim, Siew Pheng; Butcher, Rebecca E.; Yap, Thai Leong; Lescar, Julien; Wright, Peter J.; Vasudevan, Subhash G.; Davidson, Andrew D. Mutagenesis of the Dengue Virus Type 2 NS5 Methyltransferase Domain. Journal of Biological Chemistry (2008), 283(28), 19410-19421.
- Dick, Thomas; Dartois, Veronique; Keller, Thomas H.; Matter, Alex. TB drug discovery from target identification to proof of concept studies. Handbook of Tuberculosis: Clinics, Diagnostics, Therapy and Epidemiology (2008), 143-163.
- Li, Xiaojin; Manjunatha, Ujjini H.; Goodwin, Michael B.; Knox, John E.; Lipinski, Christopher A.; Keller, Thomas H.; Barry, Clifton E., III; Dowd, Cynthia S. Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824. Bioorganic & Medicinal Chemistry Letters (2008), 18(7), 2256-2262.
- Matter Alex; Keller Thomas H Impact of non-profit organizations on drug discovery: opportunities, gaps, solutions. Drug discovery today (2008), 13(7-8), 347-52.
- Hibberd, Martin Lloyd; Tolfvenstam, Thomas; Fink, Joshua; Vasudevan, Subhash; Gu, Feng. Changes in protein degradation, immune response, and regulation of apoptosis in dengue fever and their use in diagnosis and prognosis. PCT Int. Appl. (2008), 104pp.
- Rao Srinivasa P S; Camacho Luis; Huat Tan Bee; Boon Calvin; Russel David G; Dick Thomas; Pethe Kevin Recombinase-based reporter system and antisense technology to study gene expression and essentiality in hypoxic nonreplicating mycobacteria. FEMS microbiology letters (2008), 284(1), 68-75.
- Luo, Dahai; Xu, Ting; Hunke, Cornelia; Gruber, Gerhard; Vasudevan, Subhash G.; Lescar, Julien. Crystal structure of the NS3 protease-helicase from dengue virus. Journal of Virology (2008), 82(1), 173-183.
- Tanner Lukas; Schreiber Mark; Low Jenny G H; Ong Adrian; Tolfvenstam Thomas; Lai Yee Ling; Ng Lee Ching; Leo Yee Sin; Thi Puong Le; Vasudevan Subhash G; Simmons Cameron P; Hibberd Martin L; Ooi Eng Eong Decision tree algorithms predict the diagnosis and outcome of dengue Fever in the early phase of illness. PLoS neglected tropical diseases (2008), 2(3), e196.
- Ong Swee Hoe; Yip Jin Teen; Chen Yen Liang; Liu Wei; Harun Syahrial; Lystiyaningsih Erlin; Heriyanto Bambang; Beckett Charmagne G; Mitchell Wayne P; Hibberd Martin L; Suwandono Agus; Vasudevan Subhash G; Schreiber Mark J Periodic re-emergence of endemic strains with strong epidemic potential-a proposed explanation for the 2004 Indonesian dengue epidemic. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (2008), 8(2), 191-204.
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